A Phase 1 Single Ascending Dose Study Evaluating the Safety, Tolerability, and Pharmacodynamic Effects of MDK-703, an IL-7 Mimetic With Extended Half-life
Richard Friend, Bryan Baxter, Inkyung Park, Steven Cwirla, and Ronald Barrett
MDK1654: A Branched Synthetic Peptide that Activates Both the IL-7 Receptor and the bgcForm of the IL-2/15 Receptor
Angie Inkyung Park, William J. Dower, Steven E. Cwirla, Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Michael C. Needels, and Ronald W. Barrett
AACR 2022 – In vitro and in vivo properties of MDK-703, An Fc-peptide fusion IL-7Rαγc agonist unrelated in structure to IL-7
Angie I. Park, Steven E. Cwirla, Alice V. Bakker, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Sandra M. Wang, Bryan Baxter, Michael C. Needels, Ronald W. Barrett, William J. Dower
SITC 2021 - Peptidyl IL-2/15Rβγc-restricted agonists, highly-attenuated and linked to anti-PD-1 antibodies to achieve selectivity and amplify potency in stimulating PD-1 high lymphocytes
William J. Dower, Alice V. Bakker, Steven E. Cwirla, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Michael C. Needels, Ronald W. Barrett
SITC 2020 - MDK-701, a potent peptidyl agonist of IL-7R fused to an FC-domain
William J. Dower, Alice V. Bakker, Steven E. Cwirla, Prarthana Joshi, Praechompoo Pongtornpipat, Blake M. Williams, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett
SITC 2020 - MDK-271, dual agonists of IL-2R and IL-7R incorporated into a bispecific
William J. Dower, Steven E. Cwirla; Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett
SITC 2020 - MDK-202, a peptidyl agonist of IL-2R, devoid of alpha interaction, fused to an FC-domain
William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett
SITC 2019 - MK1169, a peptide unrelated to IL-2, is a potent IL-2R receptor agonist
William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett