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A Phase 1 Single Ascending Dose Study Evaluating the Safety, Tolerability, and Pharmacodynamic Effects of MDK-703, an IL-7 Mimetic With Extended Half-life

Richard Friend, Bryan Baxter, Inkyung Park, Steven Cwirla, and Ronald Barrett

MDK1654: A Branched Synthetic Peptide that Activates Both the IL-7 Receptor and the bgcForm of the IL-2/15 Receptor

Angie Inkyung Park, William J. Dower, Steven E. Cwirla, Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Michael C. Needels, and Ronald W. Barrett

PEGS Boston Summit 2022 - Discovery and Versatile Use of Peptide-Based Agonists of Hetero-Dimeric γc Cytokine Receptors

Ronald W. Barrett

AACR 2022 – In vitro and in vivo properties of MDK-703, An Fc-peptide fusion IL-7Rαγc agonist unrelated in structure to IL-7

Angie I. Park, Steven E. Cwirla, Alice V. Bakker, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Sandra M. Wang, Bryan Baxter, Michael C. Needels, Ronald W. Barrett, William J. Dower

SITC 2021 - Peptidyl IL-2/15Rβγc-restricted agonists, highly-attenuated and linked to anti-PD-1 antibodies to achieve selectivity and amplify potency in stimulating PD-1 high lymphocytes

William J. Dower, Alice V. Bakker, Steven E. Cwirla, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Michael C. Needels, Ronald W. Barrett

SITC 2020 - MDK-701, a potent peptidyl agonist of IL-7R fused to an FC-domain

William J. Dower, Alice V. Bakker, Steven E. Cwirla, Prarthana Joshi, Praechompoo Pongtornpipat, Blake M. Williams, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett

SITC 2020 - MDK-271, dual agonists of IL-2R and IL-7R incorporated into a bispecific

William J. Dower, Steven E. Cwirla; Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett

SITC 2020 - MDK-202, a peptidyl agonist of IL-2R, devoid of alpha interaction, fused to an FC-domain

William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett

SITC 2019 - MK1169, a peptide unrelated to IL-2, is a potent IL-2R receptor agonist

William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett