News & Publications

 
 
 

Press Releases

Featured
Medikine Appoints Roland Buelow, Ph.D., to Board of Directors
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Medikine Presents Preliminary Results of a Single-Dose Phase 1 Healthy Subject Study of MDK-703, a Peptide-Based Mimetic of Interleukin-7 (IL-7)
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Medikine to Present Preliminary Phase 1 Clinical Trial Results for MDK-703 at the Society for Immunotherapy of Cancer’s 37th Annual Meeting (SITC 2022)
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Medikine Initiates First Clinical Trial of its Lead Program, an Interleukin-7 Mimetic, Under Management Team with Expertise in Next-Generation Cytokine Drug Discovery and Development
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Medikine to Highlight Preclinical Data on its Lead Program MDK-703, an IL-7 Mimetic, at the 2022 Annual Meeting of the American Association for Cancer Research (AACR)
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Publications and Presentations

Featured
A Phase 1 Single Ascending Dose Study Evaluating the Safety, Tolerability, and Pharmacodynamic Effects of MDK-703, an IL-7 Mimetic With Extended Half-life

Richard Friend, Bryan Baxter, Inkyung Park, Steven Cwirla, and Ronald Barrett

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MDK1654: A Branched Synthetic Peptide that Activates Both the IL-7 Receptor and the bgcForm of the IL-2/15 Receptor

Angie Inkyung Park, William J. Dower, Steven E. Cwirla, Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Michael C. Needels, and Ronald W. Barrett

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PEGS Boston Summit 2022 - Discovery and Versatile Use of Peptide-Based Agonists of Hetero-Dimeric γc Cytokine Receptors

Ronald W. Barrett

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AACR 2022 – In vitro and in vivo properties of MDK-703, An Fc-peptide fusion IL-7Rαγc agonist unrelated in structure to IL-7

Angie I. Park, Steven E. Cwirla, Alice V. Bakker, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Sandra M. Wang, Bryan Baxter, Michael C. Needels, Ronald W. Barrett, William J. Dower

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SITC 2021 - Peptidyl IL-2/15Rβγc-restricted agonists, highly-attenuated and linked to anti-PD-1 antibodies to achieve selectivity and amplify potency in stimulating PD-1 high lymphocytes

William J. Dower, Alice V. Bakker, Steven E. Cwirla, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Michael C. Needels, Ronald W. Barrett

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SITC 2020 - MDK-701, a potent peptidyl agonist of IL-7R fused to an FC-domain

William J. Dower, Alice V. Bakker, Steven E. Cwirla, Prarthana Joshi, Praechompoo Pongtornpipat, Blake M. Williams, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett

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SITC 2020 - MDK-271, dual agonists of IL-2R and IL-7R incorporated into a bispecific

William J. Dower, Steven E. Cwirla; Alice V. Bakker, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Sandra M. Wang, Michael C. Needels, Ronald W. Barrett

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SITC 2020 - MDK-202, a peptidyl agonist of IL-2R, devoid of alpha interaction, fused to an FC-domain

William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett

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SITC 2019 - MK1169, a peptide unrelated to IL-2, is a potent IL-2R receptor agonist

William J. Dower, Steven E. Cwirla, Blake M. Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra M. Wang, Alice V. Bakker, Michael C. Needels, Ronald W. Barrett

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